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Solution structure of a paradigm ArsR family zinc sensor in the DNA-bound state

Staphylococcus aureus CzrA is a zinc-dependent transcriptional repressor from the ubiquitous ArsR family of metal sensor proteins. Zn(II) binds to a pair of intersubunit C-terminal α5-sensing sites, some 15 Å distant from the DNA-binding interface, and allosterically inhibits DNA binding. This regul...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Arunkumar, Alphonse I., Campanello, Gregory C., Giedroc, David P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775347/
https://ncbi.nlm.nih.gov/pubmed/19822742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905558106
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