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Solution structure of a paradigm ArsR family zinc sensor in the DNA-bound state
Staphylococcus aureus CzrA is a zinc-dependent transcriptional repressor from the ubiquitous ArsR family of metal sensor proteins. Zn(II) binds to a pair of intersubunit C-terminal α5-sensing sites, some 15 Å distant from the DNA-binding interface, and allosterically inhibits DNA binding. This regul...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2775347/ https://ncbi.nlm.nih.gov/pubmed/19822742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905558106 |
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