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Discriminative Stimulus Effects of 1-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane (DOM), Ketanserin, and (R)-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol (MDL100907) in Rats

Very little is known about constitutive activity in vivo. This study examined whether constitutive activity and inverse agonism contribute to discriminative stimulus effects of drugs acting at serotonin (5-HT)(2A) receptors. Rats were trained to discriminate between saline and either 0.56 mg/kg 5-HT...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Li, Jun-Xu, Unzeitig, Alison, Javors, Martin A., Rice, Kenner C., Koek, Wouter, France, Charles P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Pharmacology and Experimental Therapeutics 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775261/
https://ncbi.nlm.nih.gov/pubmed/19687292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.157560
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