Discriminative Stimulus Effects of 1-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane (DOM), Ketanserin, and (R)-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol (MDL100907) in Rats

Very little is known about constitutive activity in vivo. This study examined whether constitutive activity and inverse agonism contribute to discriminative stimulus effects of drugs acting at serotonin (5-HT)(2A) receptors. Rats were trained to discriminate between saline and either 0.56 mg/kg 5-HT...

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Detalhes bibliográficos
Main Authors: Li, Jun-Xu, Unzeitig, Alison, Javors, Martin A., Rice, Kenner C., Koek, Wouter, France, Charles P.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2009
Assuntos:
Behavioral Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775261/
https://ncbi.nlm.nih.gov/pubmed/19687292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.157560
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