A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation

Transmembrane protein tyrosine phosphatases, such as CD45, can act as both positive and negative regulators of cellular signaling. CD45 positively modulates T cell receptor (TCR) signaling by constitutively priming p56lck through the dephosphorylation of the C-terminal negative regulatory phosphotyr...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Johnson, Kenneth G., Bromley, Shannon K., Dustin, Michael L., Thomas, Matthew L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27752/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10963676/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.18.10138
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