Mycolactone Gene Expression Is Controlled by Strong SigA-Like Promoters with Utility in Studies of Mycobacterium ulcerans and Buruli Ulcer

Mycolactone A/B is a lipophilic macrocyclic polyketide that is the primary virulence factor produced by Mycobacterium ulcerans, a human pathogen and the causative agent of Buruli ulcer. In M. ulcerans strain Agy99 the mycolactone polyketide synthase (PKS) locus spans a 120 kb region of a 174 kb mega...

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Detalhes bibliográficos
Main Authors: Tobias, Nicholas J., Seemann, Torsten, Pidot, Sacha J., Porter, Jessica L., Marsollier, Laurent, Marion, Estelle, Letournel, Franck, Zakir, Tasnim, Azuolas, Joseph, Wallace, John R., Hong, Hui, Davies, John K., Howden, Benjamin P., Johnson, Paul D. R., Jenkin, Grant A., Stinear, Timothy P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775157/
https://ncbi.nlm.nih.gov/pubmed/19936295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0000553
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