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Use of A U16 snoRNA-containing Ribozyme Library to Identify Ribozyme Targets in HIV-1
Hammerhead ribozymes have been shown to silence human immunodeficiency virus-1 (HIV-1) gene expression by site-specific cleavage of viral mRNA. The two major factors that determine whether ribozymes will be effective for post-transcriptional gene silencing are colocalization of the ribozyme and the...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2775071/ https://ncbi.nlm.nih.gov/pubmed/18388915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.54 |
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