Attenuation of IgG immune complex-induced acute lung injury by silencing C5aR in lung epithelial cells

Acute lung injury (ALI) in mouse lung occurs after distal airway deposition of IgG immune complexes (IgGICs), resulting in a breakdown of the vascular-airway barrier, causing intrapulmonary edema, hemorrhage, and accumulation of neutrophils [polymorphonuclear leukocytes (PMNs)] in the alveolar compa...

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Bibliografiska uppgifter
Huvudupphovsmän: Sun, Lei, Guo, Ren-Feng, Gao, Hongwei, Sarma, J. Vidya, Zetoune, Firas S., Ward, Peter A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Federation of American Societies for Experimental Biology 2009
Ämnen:
Research Communications
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775006/
https://ncbi.nlm.nih.gov/pubmed/19620403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-133694
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