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H-Ras Expression in Immortalized Keratinocytes Produces an Invasive Epithelium in Cultured Skin Equivalents

BACKGROUND: Ras proteins affect both proliferation and expression of collagen-degrading enzymes, two important processes in cancer progression. Normal skin architecture is dependent both on the coordinated proliferation and stratification of keratinocytes, as well as the maintenance of a collagen-ri...

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Detalhes bibliográficos
Main Authors: Vaughan, Melville B., Ramirez, Ruben D., Andrews, Capri M., Wright, Woodring E., Shay, Jerry W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774948/
https://ncbi.nlm.nih.gov/pubmed/19936293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007908
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