Viral RNA Induces Type I Interferon-Dependent Cytokine Release and Cell Death in Mesangial Cells via Melanoma-Differentiation-Associated Gene-5 : Implications for Viral Infection-Associated Glomerulonephritis

Viral RNA can trigger interferon signaling in dendritic cells via the innate recognition receptors melanoma-differentiation-associated gene (MDA)-5 and retinod-inducible gene (RIG)-I in the cytosol or via Toll-like receptors (TLRs) in intracellular endosomes. We hypothesized that viral RNA would als...

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Main Authors: Flür, Katharina, Allam, Ramanjaneyulu, Zecher, Daniel, Kulkarni, Onkar P., Lichtnekert, Julia, Schwarz, Martin, Beutler, Bruce, Vielhauer, Volker, Anders, Hans-Joachim
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774065/
https://ncbi.nlm.nih.gov/pubmed/19850889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080585
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