Polypodium leucotomos Extract Decreases UV-Induced Cox-2 Expression and Inflammation, Enhances DNA Repair, and Decreases Mutagenesis in Hairless Mice

UV-irradiated skin and UV-induced tumors overexpress the inducible isoform of cyclooxygenase-2 (Cox-2), and Cox-2 inhibition reduces photocarcinogenesis. To evaluate photoprotective effects of Polypodium leucotomos extract (PL), hairless Xpc(+/−) mice were fed for 10 days with PL (300 mg/kg) or vehi...

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Hauptverfasser: Zattra, Edoardo, Coleman, Christina, Arad, Simin, Helms, Elizabeth, Levine, Danielle, Bord, Evelyn, Guillaume, Alexandra, El-Hajahmad, Mohamad, Zwart, Edwin, van Steeg, Harry, Gonzalez, Salvador, Kishore, Raj, Goukassian, David A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2009
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Regular Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774059/
https://ncbi.nlm.nih.gov/pubmed/19808641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.090351
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