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Methionine oxidation contributes to bacterial killing by the myeloperoxidase system of neutrophils

Reactive oxygen intermediates generated by neutrophils kill bacteria and are implicated in inflammatory tissue injury, but precise molecular targets are undefined. We demonstrate that neutrophils use myeloperoxidase (MPO) to convert methionine residues of ingested Escherichia coli to methionine sulf...

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Detalhes bibliográficos
Main Authors: Rosen, Henry, Klebanoff, Seymour J., Wang, Yi, Brot, Nathan, Heinecke, Jay W., Fu, Xiaoyun
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774013/
https://ncbi.nlm.nih.gov/pubmed/19833874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909464106
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