Smad4-dependent pathways control basement membrane deposition and endodermal cell migration at early stages of mouse development

BACKGROUND: Smad4 mutant embryos arrest shortly after implantation and display a characteristic shortened proximodistal axis, a significantly reduced epiblast, as well as a thickened visceral endoderm layer. Conditional rescue experiments demonstrate that bypassing the primary requirement for Smad4...

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Bibliografiske detaljer
Main Authors: Costello, Ita, Biondi, Christine A, Taylor, Jennifer M, Bikoff, Elizabeth K, Robertson, Elizabeth J
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773778/
https://ncbi.nlm.nih.gov/pubmed/19849841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-213X-9-54
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