A Mixed Integer Linear Optimization Framework for the Identification and Quantification of Targeted Post-translational Modifications of Highly Modified Proteins Using Multiplexed Electron Transfer Dissociation Tandem Mass Spectrometry

Here we present a novel methodology for the identification of the targeted post-translational modifications present in highly modified proteins using mixed integer linear optimization and electron transfer dissociation (ETD) tandem mass spectrometry. For a given ETD tandem mass spectrum, the rigorou...

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Detalhes bibliográficos
Main Authors: DiMaggio, Peter A., Young, Nicolas L., Baliban, Richard C., Garcia, Benjamin A., Floudas, Christodoulos A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773719/
https://ncbi.nlm.nih.gov/pubmed/19666874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M900144-MCP200
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