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Substrate binding site flexibility of the small heat shock protein molecular chaperones

Small heat shock proteins (sHSPs) serve as a first line of defense against stress-induced cell damage by binding and maintaining denaturing proteins in a folding-competent state. In contrast to the well-defined substrate binding regions of ATP-dependent chaperones, interactions between sHSPs and sub...

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Main Authors: Jaya, Nomalie, Garcia, Victor, Vierling, Elizabeth
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773522/
https://ncbi.nlm.nih.gov/pubmed/19717454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902177106
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