The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element

The p53 target gene Wig-1 encodes a double-stranded-RNA-binding zinc finger protein. We show here that Wig-1 binds to p53 mRNA and stabilizes it through an AU-rich element (ARE) in the 3′ UTR of the p53 mRNA. This effect is mirrored by enhanced p53 protein levels in both unstressed cells and cells e...

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Main Authors: Vilborg, Anna, Glahder, Jacob A., Wilhelm, Margareta T., Bersani, Cinzia, Corcoran, Martin, Mahmoudi, Salah, Rosenstierne, Maiken, Grandér, Dan, Farnebo, Marianne, Norrild, Bodil, Wiman, Klas G.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773521/
https://ncbi.nlm.nih.gov/pubmed/19805223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900862106
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