Загрузка...
The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element
The p53 target gene Wig-1 encodes a double-stranded-RNA-binding zinc finger protein. We show here that Wig-1 binds to p53 mRNA and stabilizes it through an AU-rich element (ARE) in the 3′ UTR of the p53 mRNA. This effect is mirrored by enhanced p53 protein levels in both unstressed cells and cells e...
Сохранить в:
| Главные авторы: | , , , , , , , , , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2009
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2773521/ https://ncbi.nlm.nih.gov/pubmed/19805223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900862106 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|