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The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element
The p53 target gene Wig-1 encodes a double-stranded-RNA-binding zinc finger protein. We show here that Wig-1 binds to p53 mRNA and stabilizes it through an AU-rich element (ARE) in the 3′ UTR of the p53 mRNA. This effect is mirrored by enhanced p53 protein levels in both unstressed cells and cells e...
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主要な著者: | , , , , , , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
National Academy of Sciences
2009
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2773521/ https://ncbi.nlm.nih.gov/pubmed/19805223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900862106 |
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