Genotyping of Genetically Monomorphic Bacteria: DNA Sequencing in Mycobacterium tuberculosis Highlights the Limitations of Current Methodologies

Because genetically monomorphic bacterial pathogens harbour little DNA sequence diversity, most current genotyping techniques used to study the epidemiology of these organisms are based on mobile or repetitive genetic elements. Molecular markers commonly used in these bacteria include Clustered Regu...

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Bibliographic Details
Main Authors: Comas, Iñaki, Homolka, Susanne, Niemann, Stefan, Gagneux, Sebastien
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772813/
https://ncbi.nlm.nih.gov/pubmed/19915672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007815
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