VP5* Rearranges when Rotavirus Uncoats

Trypsin primes rotavirus for efficient infectivity by cleaving the spike protein, VP4, into VP8* and VP5*. A recombinant VP5* fragment has a trimeric, folded-back structure. Comparison of this structure with virion spikes suggests that a rearrangement, analogous to those of enveloped virus fusion pr...

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Hlavní autoři: Yoder, Joshua D., Trask, Shane D., Vo, Phuoc T., Binka, Mawuena, Feng, Ningguo, Harrison, Stephen C., Greenberg, Harry B., Dormitzer, Philip R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2009
Témata:
Structure and Assembly
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772785/
https://ncbi.nlm.nih.gov/pubmed/19692464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01228-09
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