Mechanism of Human Immunodeficiency Virus Type 1 Resistance to Monoclonal Antibody b12 That Effectively Targets the Site of CD4 Attachment

The region of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 that engages its primary cellular receptor CD4 forms a site of vulnerability to neutralizing antibodies. The monoclonal antibody b12 exploits the conservation and accessibility of the CD4-binding site to neutra...

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Bibliographic Details
Main Authors: Wu, Xueling, Zhou, Tongqing, O'Dell, Sijy, Wyatt, Richard T., Kwong, Peter D., Mascola, John R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772753/
https://ncbi.nlm.nih.gov/pubmed/19692465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01142-09
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