Impact of Novel Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutations P119S and T165A on 4′-Ethynylthymidine Analog Resistance Profile

2′,3′-Didehydro-3′-deoxy-4′-ethynylthymidine (4′-Ed4T), a derivative of stavudine (d4T), has potent activity against human immunodeficiency virus and is much less inhibitory to mitochondrial DNA synthesis and cell growth than its progenitor, d4T. 4′-Ed4T triphosphate was a better reverse transcripta...

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Bibliographic Details
Main Authors: Yang, Guangwei, Paintsil, Elijah, Dutschman, Ginger E., Grill, Susan P., Wang, Chuan-Jen, Wang, Jimin, Tanaka, Hiromichi, Hamasaki, Takayuki, Baba, Masanori, Cheng, Yung-Chi
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772322/
https://ncbi.nlm.nih.gov/pubmed/19704131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00686-09
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