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Impact of Novel Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutations P119S and T165A on 4′-Ethynylthymidine Analog Resistance Profile
2′,3′-Didehydro-3′-deoxy-4′-ethynylthymidine (4′-Ed4T), a derivative of stavudine (d4T), has potent activity against human immunodeficiency virus and is much less inhibitory to mitochondrial DNA synthesis and cell growth than its progenitor, d4T. 4′-Ed4T triphosphate was a better reverse transcripta...
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Hauptverfasser: | , , , , , , , , , |
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Format: | Artigo |
Sprache: | Inglês |
Veröffentlicht: |
American Society for Microbiology (ASM)
2009
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Schlagworte: | |
Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2772322/ https://ncbi.nlm.nih.gov/pubmed/19704131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00686-09 |
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