Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4/MyD88 pathway

PROBLEM: Women with antiphospholipid antibodies (aPL) are at risk for recurrent miscarriage, preeclampsia and preterm labor. aPL target the placenta directly by binding to Beta(2)-Glycoprotein I (β(2)GPI) expressed on the surface of trophoblast cells. The objective of this study was to determine the...

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Main Authors: Mulla, Melissa J., Brosens, Jan J., Chamley, Larry W., Giles, Ian, Pericleous, Charis, Rahman, Anisur, Joyce, Shawna K., Panda, Britta, Paidas, Michael J., Abrahams, Vikki M.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772057/
https://ncbi.nlm.nih.gov/pubmed/19614626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0897.2009.00717.x
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