Impact of adding a single allele in the 9p21 locus to traditional risk factors on reclassification of coronary heart disease risk and implications for lipid-modifying therapy in the Atherosclerosis Risk in Communities (ARIC) study

BACKGROUND: A single nucleotide polymorphism on chromosome 9p21, rs10757274 (9p21 allele), has been shown to predict coronary heart disease (CHD) in whites. We evaluated whether adding the 9p21 allele to traditional risk factors (RF) improved CHD risk prediction in whites from the Atherosclerosis Ri...

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Hlavní autoři: Brautbar, Ariel, Ballantyne, Christie M, Lawson, Kim, Nambi, Vijay, Chambless, Lloyd, Folsom, Aaron R, Willerson, James T., Boerwinkle, Eric
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771929/
https://ncbi.nlm.nih.gov/pubmed/20031596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.108.817338
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