Impact of adding a single allele in the 9p21 locus to traditional risk factors on reclassification of coronary heart disease risk and implications for lipid-modifying therapy in the Atherosclerosis Risk in Communities (ARIC) study

BACKGROUND: A single nucleotide polymorphism on chromosome 9p21, rs10757274 (9p21 allele), has been shown to predict coronary heart disease (CHD) in whites. We evaluated whether adding the 9p21 allele to traditional risk factors (RF) improved CHD risk prediction in whites from the Atherosclerosis Ri...

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Detalhes bibliográficos
Main Authors: Brautbar, Ariel, Ballantyne, Christie M, Lawson, Kim, Nambi, Vijay, Chambless, Lloyd, Folsom, Aaron R, Willerson, James T., Boerwinkle, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771929/
https://ncbi.nlm.nih.gov/pubmed/20031596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.108.817338
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