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Activation of the West Nile virus NS3 protease: Molecular dynamics evidence for a conformational selection mechanism
The flaviviral nonstructural 3 protease (NS3pro) is essential for virus replication and is therefore a pharmaceutically relevant target to fight Dengue and West Nile virus (WNV). NS3pro is a chymotrypsin-like serine protease which requires a polypeptide cofactor (NS2B) for activation. Recent X-ray c...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Wiley Subscription Services, Inc., A Wiley Company
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2771302/ https://ncbi.nlm.nih.gov/pubmed/19388022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.110 |
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