Discovery of a Non-Peptidic Inhibitor of West Nile Virus NS3 Protease by High-Throughput Docking

BACKGROUND: The non-structural 3 protease (NS3pro) is an essential flaviviral enzyme and therefore one of the most promising targets for drug development against West Nile virus (WNV) and dengue infections. METHODOLOGY: In this work, a small-molecule inhibitor of the WNV NS3pro has been identified b...

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Autors principals: Ekonomiuk, Dariusz, Su, Xun-Cheng, Ozawa, Kiyoshi, Bodenreider, Christophe, Lim, Siew Pheng, Yin, Zheng, Keller, Thomas H., Beer, David, Patel, Viral, Otting, Gottfried, Caflisch, Amedeo, Huang, Danzhi
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613028/
https://ncbi.nlm.nih.gov/pubmed/19159012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0000356
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