Unbalancing the Phosphatidylinositol-4,5-bisphosphate–Cofilin Interaction Impairs Cell Steering

Cofilin is a key player in actin dynamics during cell migration. Its activity is regulated by (de)phosphorylation, pH, and binding to phosphatidylinositol-4,5-bisphosphate [PI(4,5)P(2)]. Here, we here use a human cofilin-1 (D122K) mutant with increased binding affinity for PI(4,5)P(2) and slower rel...

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Autori principali: Leyman, Shirley, Sidani, Mazen, Ritsma, Laila, Waterschoot, Davy, Eddy, Robert, Dewitte, Daisy, Debeir, Olivier, Decaestecker, Christine, Vandekerckhove, Joël, van Rheenen, Jacco, Ampe, Christophe, Condeelis, John, Van Troys, Marleen
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770939/
https://ncbi.nlm.nih.gov/pubmed/19741095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-02-0121
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