Increased MKK4 abundance with replicative senescence is linked to the joint reduction of multiple microRNAs

MAPK (mitogen-activated protein kinase) kinase 4 (MKK4) is a pivotal upstream activator of c-Jun-N-terminal kinase (JNK) and p38(MAPK). Here, we report that MKK4 is increased in senescent human diploid fibroblasts (HDFs) through enhanced translation. We identified four microRNAs (miR-15b, miR-24, mi...

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Bibliographische Detailangaben
Hauptverfasser: Marasa, Bernard S., Srikantan, Subramanya, Masuda, Kiyoshi, Abdelmohsen, Kotb, Kuwano, Yuki, Yang, Xiaoling, Martindale, Jennifer L., Rinker-Schaeffer, Carrie W., Gorospe, Myriam
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770878/
https://ncbi.nlm.nih.gov/pubmed/19861690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000442
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