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Increased MKK4 abundance with replicative senescence is linked to the joint reduction of multiple microRNAs
MAPK (mitogen-activated protein kinase) kinase 4 (MKK4) is a pivotal upstream activator of c-Jun-N-terminal kinase (JNK) and p38(MAPK). Here, we report that MKK4 is increased in senescent human diploid fibroblasts (HDFs) through enhanced translation. We identified four microRNAs (miR-15b, miR-24, mi...
में बचाया:
| मुख्य लेखकों: | , , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2009
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2770878/ https://ncbi.nlm.nih.gov/pubmed/19861690 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000442 |
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