Epac increases melanoma cell migration by a heparan sulfate-related mechanism

Melanoma, the most malignant form of human skin cancer, has a poor prognosis due to its strong metastatic ability. It was recently demonstrated that Epac, an effector molecule of cAMP, is involved in regulating cell migration; however, the role of Epac in melanoma cell migration remains unclear. We...

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Main Authors: Baljinnyam, Erdene, Iwatsubo, Kousaku, Kurotani, Reiko, Wang, Xu, Ulucan, Coskun, Iwatsubo, Mizuka, Lagunoff, David, Ishikawa, Yoshihiro
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2009
Teme:
Receptors and Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770742/
https://ncbi.nlm.nih.gov/pubmed/19657062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00129.2009
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