The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links

Both the ERCC1-XPF complex and the proteins involved in homoIogous recombination (HR) have critical roles in inter-strand cross-link (ICL) repair. Here, we report that mitomycin C-induced lesions inhibit replication fork elongation. Furthermore, mitomycin C-induced DNA double-strand breaks (DSBs) ar...

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Detalhes bibliográficos
Main Authors: Al-Minawi, Ali Z., Lee, Yin-Fai, Håkansson, Daniel, Johansson, Fredrik, Lundin, Cecilia, Saleh-Gohari, Nasrollah, Schultz, Niklas, Jenssen, Dag, Bryant, Helen E., Meuth, Mark, Hinz, John M., Helleday, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770670/
https://ncbi.nlm.nih.gov/pubmed/19713438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp705
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