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RNA polymerase III can drive polycistronic expression of functional interfering RNAs designed to resemble microRNAs

In both research and therapeutic applications of RNA interference, it is often advantageous to silence several targets simultaneously. Toward this end, several groups have developed vectors that utilize the model of endogenously encoded micro (mi) RNAs, where a single RNA polymerase II promoter can...

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Bibliografski detalji
Glavni autori: Snyder, Lindsey L., Ahmed, Iqbal, Steel, Laura F.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770651/
https://ncbi.nlm.nih.gov/pubmed/19679642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp657
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