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Accounting for Near-Normal Glucose Sensitivity in K(ir)6.2[AAA] Transgenic Mice
K(ir)6.2[AAA] transgenic mouse islets exhibit mosaicism such that ∼70% of the β-cells have nonfunctional ATP-sensitive potassium (K(ATP)) channels, whereas the remainder have normal K(ATP) function. Despite this drastic reduction, the glucose dose-response curve is only shifted by ∼2 mM. We use a pr...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Biophysical Society
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2770618/ https://ncbi.nlm.nih.gov/pubmed/19883583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.07.060 |
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