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Accounting for Near-Normal Glucose Sensitivity in K(ir)6.2[AAA] Transgenic Mice

K(ir)6.2[AAA] transgenic mouse islets exhibit mosaicism such that ∼70% of the β-cells have nonfunctional ATP-sensitive potassium (K(ATP)) channels, whereas the remainder have normal K(ATP) function. Despite this drastic reduction, the glucose dose-response curve is only shifted by ∼2 mM. We use a pr...

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書誌詳細
主要な著者: Tsaneva-Atanasova, Krasimira, Sherman, Arthur
フォーマット: Artigo
言語:Inglês
出版事項: The Biophysical Society 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770618/
https://ncbi.nlm.nih.gov/pubmed/19883583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.07.060
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