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Counteraction of Urea by Trimethylamine N-Oxide Is Due to Direct Interaction

Trimethylamine N-oxide (TMAO) is a naturally occurring osmolyte that stabilizes proteins, induces folding, and counteracts the denaturing effects of urea, pressure, and ice. To establish the mechanism behind these effects, isotopic substitution neutron-scattering measurements were performed on aqueo...

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Detalles Bibliográficos
Main Authors: Meersman, Filip, Bowron, Daniel, Soper, Alan K., Koch, Michel H.J.
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770612/
https://ncbi.nlm.nih.gov/pubmed/19883599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.08.017
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