Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in Acute Myeloid Leukemia

BACKGROUND: Translocations of the Mixed Lineage Leukemia (MLL) gene occur in a subset (5%) of acute myeloid leukemias (AML), and in mixed phenotype acute leukemias in infancy - a disease with extremely poor prognosis. Animal model systems show that MLL gain of function mutations may contribute to le...

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Autori principali: Röhrs, Sonja, Dirks, Wilhelm G, Meyer, Claus, Marschalek, Rolf, Scherr, Michaela, Slany, Robert, Wallace, Andrew, Drexler, Hans G, Quentmeier, Hilmar
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2009
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770485/
https://ncbi.nlm.nih.gov/pubmed/19835597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-8-86
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