Myostatin represses physiological hypertrophy of the heart and excitation–contraction coupling

Although myostatin negatively regulates skeletal muscle growth, its function in heart is virtually unknown. Herein we demonstrate that it inhibits basal and IGF-stimulated proliferation and differentiation and also modulates cardiac excitation–contraction (EC) coupling. Loss of myostatin induced ecc...

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Bibliographic Details
Main Authors: Rodgers, Buel D, Interlichia, Jillian P, Garikipati, Dilip K, Mamidi, Ranganath, Chandra, Murali, Nelson, O Lynne, Murry, Charles E, Santana, Luis F
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2009
Subjects:
Cardiovascular
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770153/
https://ncbi.nlm.nih.gov/pubmed/19736304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2009.172544
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