Myostatin represses physiological hypertrophy of the heart and excitation–contraction coupling

Although myostatin negatively regulates skeletal muscle growth, its function in heart is virtually unknown. Herein we demonstrate that it inhibits basal and IGF-stimulated proliferation and differentiation and also modulates cardiac excitation–contraction (EC) coupling. Loss of myostatin induced ecc...

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Autors principals: Rodgers, Buel D, Interlichia, Jillian P, Garikipati, Dilip K, Mamidi, Ranganath, Chandra, Murali, Nelson, O Lynne, Murry, Charles E, Santana, Luis F
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2009
Matèries:
Cardiovascular
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770153/
https://ncbi.nlm.nih.gov/pubmed/19736304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2009.172544
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