NK-like homeodomain proteins activate NOTCH3-signaling in leukemic T-cells

BACKGROUND: Homeodomain proteins control fundamental cellular processes in development and in cancer if deregulated. Three members of the NK-like subfamily of homeobox genes (NKLs), TLX1, TLX3 and NKX2-5, are implicated in T-cell acute lymphoblastic leukemia (T-ALL). They are activated by particular...

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Main Authors: Nagel, Stefan, Venturini, Letizia, Przybylski, Grzegorz K, Grabarczyk, Piotr, Meyer, Corinna, Kaufmann, Maren, Battmer, Karin, Schmidt, Christian A, Drexler, Hans G, Scherr, Michaela, MacLeod, Roderick AF
Format: Artigo
Language:Inglês
Published: BioMed Central 2009
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770077/
https://ncbi.nlm.nih.gov/pubmed/19835636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-9-371
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