NKL homeobox gene activities in hematopoietic stem cells, T-cell development and T-cell leukemia

T-cell acute lymphoblastic leukemia (T-ALL) cells represent developmentally arrested T-cell progenitors, subsets of which aberrantly express homeobox genes of the NKL subclass, including TLX1, TLX3, NKX2-1, NKX2-5, NKX3-1 and MSX1. Here, we analyzed the transcriptional landscape of all 48 members of...

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Udgivet i:PLoS One
Main Authors: Nagel, Stefan, Pommerenke, Claudia, Scherr, Michaela, Meyer, Corinna, Kaufmann, Maren, Battmer, Karin, MacLeod, Roderick A. F., Drexler, Hans G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5289504/
https://ncbi.nlm.nih.gov/pubmed/28151996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171164
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