Overactive Beta-Catenin Signaling Causes Testicular Sertoli Cell Tumor Development in the Mouse

Overactive WNT/beta-catenin signaling has been found in many forms of cancer in human patients. Mouse models with mutations in different components of the WNT/beta-catenin signaling pathway have been generated to mimic tumorigenesis in humans. Mice with mutations that result in overactive WNT/beta-c...

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Bibliographic Details
Main Authors: Chang, Hao, Guillou, Florian, Taketo, Makoto M., Behringer, Richard R.
Format: Artigo
Language:Inglês
Published: Society for the Study of Reproduction, Inc. 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770017/
https://ncbi.nlm.nih.gov/pubmed/19553598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.109.077446
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