Release of HMGB1 in response to pro-apoptotic glioma killing strategies: efficacy and neurotoxicity

PURPOSE: In preparation for a Phase I clinical trial utilizing a combined cytotoxic/immunotherapeutic strategy using adenoviruses expressing Flt3L (Ad-Flt3L) and thymidine kinase (Ad-TK) to treat glioblastoma (GBM), we tested the hypothesis that Ad-TK+GCV would be the optimal tumor killing agent in...

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Main Authors: Candolfi, Marianela, Yagiz, Kader, Foulad, David, Alzadeh, Gabrielle E, Tesarfreund, Matthew, Muhammad, AKM G, Puntel, Mariana, Kroeger, Kurt M, Liu, Chunyan, Lee, Sharon, Curtin, James F, King, Gwendalyn D, Lerner, Jonathan, Sato, Katsuaki, Mineharu, Yohei, Xiong, Weidong, Lowenstein, Pedro R, Castro, Maria G
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769255/
https://ncbi.nlm.nih.gov/pubmed/19570774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-0155
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