Leukotriene E(4)–induced pulmonary inflammation is mediated by the P2Y(12) receptor

Of the potent lipid inflammatory mediators comprising the cysteinyl leukotrienes (LTs; LTC(4), LTD(4), and LTE(4)), only LTE(4) is stable and abundant in vivo. Although LTE(4) shows negligible activity at the type 1 and 2 receptors for cys-LTs (CysLT(1)R and CysLT(2)R), it is a powerful inducer of m...

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Detalhes bibliográficos
Main Authors: Paruchuri, Sailaja, Tashimo, Hiroyuki, Feng, Chunli, Maekawa, Akiko, Xing, Wei, Jiang, Yongfeng, Kanaoka, Yoshihide, Conley, Pamela, Boyce, Joshua A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768854/
https://ncbi.nlm.nih.gov/pubmed/19822647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091240
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