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A Continuum of Cell States Spans Pluripotency and Lineage Commitment in Human Embryonic Stem Cells

BACKGROUND: Commitment in embryonic stem cells is often depicted as a binary choice between alternate cell states, pluripotency and specification to a particular germ layer or extraembryonic lineage. However, close examination of human ES cell cultures has revealed significant heterogeneity in the s...

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Detalhes bibliográficos
Main Authors: Hough, Shelley R., Laslett, Andrew L., Grimmond, Sean B., Kolle, Gabriel, Pera, Martin F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768791/
https://ncbi.nlm.nih.gov/pubmed/19890402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007708
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