MT2-MMP-dependent release of collagen IV NC1 domains regulates submandibular gland branching morphogenesis

Proteolysis is essential during branching morphogenesis, but the roles of MT-MMPs and their proteolytic products are not clearly understood. Here we discover that decreasing MT-MMP activity during submandibular gland branching morphogenesis decreases proliferation and increases collagen IV and MT-MM...

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Detalhes bibliográficos
Main Authors: Rebustini, Ivan T., Myers, Christopher, Lassiter, Keyonica S., Surmak, Andrew, Szabova, Ludmila, Holmbeck, Kenn, Pedchenko, Vadim, Hudson, Billy G., Hoffman, Matthew P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768621/
https://ncbi.nlm.nih.gov/pubmed/19853562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2009.07.016
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