Specific Heparan Sulfate Structures Modulate FGF10-mediated Submandibular Gland Epithelial Morphogenesis and Differentiation

FGF10, a heparan sulfate (HS)-binding growth factor, is required for branching morphogenesis of mouse submandibular glands (SMGs). HS increases the affinity of FGF10 for FGFR2b, which forms an FGF10·FGFR2b·HS ternary signaling complex, and results in diverse biological outcomes, including proliferat...

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Detalhes bibliográficos
Main Authors: Patel, Vaishali N., Likar, Karen M., Zisman-Rozen, Simona, Cowherd, Samuel N., Lassiter, Keyonica S., Sher, Ifat, Yates, Edwin A., Turnbull, Jeremy E., Ron, Dina, Hoffman, Matthew P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431040/
https://ncbi.nlm.nih.gov/pubmed/18230614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709995200
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