Leptin regulation of bone mass, appetite and energy expenditure relies on its ability to inhibit serotonin synthesis in the brainstem

Leptin inhibition of bone mass accrual requires the integrity of specific hypothalamic neurons but not expression of its receptor on these neurons. The same is true for its regulation of appetite and energy expenditure. This suggests that leptin acts elsewhere in the brain to achieve these three fun...

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Detalhes bibliográficos
Main Authors: Yadav, Vijay K., Oury, Franck, Suda, Nina, Liu, Zhong-Wu, Gao, Xiao-Bing, Confavreux, Cyrille, Klemenhagen, Kristen C, Tanaka, Kenji F., Gingrich, Jay A., Guo, X. Edward, Tecott, Laurence H., Mann, J. John, Hen, Rene, Horvath, Tamas L., Karsenty, Gerard
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768582/
https://ncbi.nlm.nih.gov/pubmed/19737523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.06.051
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