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Essential role of c-Abl PxxP motifs and its interactions with Crk and Nck adaptors in cell spreading

The dynamic reorganization of actin structures helps to mediate the interaction of cells with their environment, and the c-Abl non-receptor tyrosine kinase can modulate actin rearrangement during cell attachment. Here we report that the c-Abl PxxP motifs, which bind Src Homology 3 (SH3) domains, are...

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Autori principali: Antoku, Susumu, Saksela, Kalle, Rivera, Gonzalo M., Mayer, Bruce J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768557/
https://ncbi.nlm.nih.gov/pubmed/18768933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.031575
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