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Differential regulation of P2X7 receptor activation by extracellular NAD and ecto-ARTs in murine macrophages and T cells

Extracellular NAD induces the ATP-independent activation of the ionotropic P2X7 purinergic receptor (P2X7R) in murine T lymphocytes via a novel covalent pathway involving ADP-ribosylation of arginine residues on the P2X7R ecto-domain. This modification is catalyzed by ART2.2, a GPI-anchored ADP-ribo...

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Detalhes bibliográficos
Main Authors: Hong, Shiyuan, Schwarz, Nicole, Brass, Anette, Seman, Michel, Haag, Friedrich, Koch-Nolte, Friedrich, Schilling, William P., Dubyak, George R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768492/
https://ncbi.nlm.nih.gov/pubmed/19542469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0900120
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