Oxidized Lipoproteins Inhibit Surfactant Phosphatidylcholine Synthesis via Calpain-mediated Cleavage of CTP:Phosphocholine Cytidylyltransferase

We investigated effects of pro-atherogenic oxidized lipoproteins on phosphatidylcholine (PtdCho) biosynthesis in murine lung epithelial cells (MLE-12). Cells surface-bound, internalized, and degraded oxidized low density lipoproteins (Ox-LDL). Ox-LDL significantly reduced [(3)H]choline incorporation...

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Bibliographic Details
Main Authors: Zhou, Jiming, Ryan, Alan J., Medh, Jheem, Mallampalli, Rama K.
Format: Artigo
Language:Inglês
Published: 2003
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768468/
https://ncbi.nlm.nih.gov/pubmed/12857760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M304316200
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